For those of us who live lives that aren't centered around running, a three-day training week might make the most sense. In using a three-day plan, you can omit what some athletes call "garbage miles."
To make it work, follow the usual advice to alternate hard days with easy days. The three running days should all be hard workouts. On the other four days, you can mix in weight and cross training.
In stripping your training program to its essence, one is a long run, one is a tempo run, and one is a speed workout.
What you should do: Pierce does interval training on Tuesdays, tempo training on Thursdays, and a long run on Sundays. For interval repeats, he runs 12 x 400 meters or 6 x 800 meters at slightly faster than his 5-K race pace. On tempo days, he runs 4 miles at a pace that's 10 to 20 seconds per mile slower than 10-K race pace. On Sundays, he runs 15 miles at a pace that's 30 seconds per mile slower than his marathon race pace. You can easily adapt these workouts to your own 5K, 10K, and marathon race paces.